Friday, April 03, 2009

Blue eyes follow-up

According to this paper, blue eyes in N. European humans is predicted very well by these variants:
HERC2 rs12913832
OCA2 rs1800407
SLC24A4 rs12896399
SLC45A2 rs16891982
TYR rs1393350
IRF4 rs12203592

It might be interesting to look at the five latter ones in the blue-eyed lemur... although, it looks like only one SNP (in HERC2, I assume) is sufficient to explain the majority of the variation in humans.


pconroy said...


Thanks for listing the salient SNPs for each of these genes. However, may I ask, do you know the ancestral or derived alleles to look for. e.g. rs12913832 G --> T etc.

The reason I ask is that a growing number of genetic enthusiasts like myself, have been tested by 23andMe or such, and would like to compare SNP's.

Thanks in advance.

Yann Klimentidis said...

Hi if I were you, I would go to this website,

and type in the SNP in the search box, then under "details" click on the little yellow triangle that corresponds to the rs# and that should give you a geographic breakdown and tell you which allele is ancestral

pconroy said...

Thanks Yann, that really helps a lot!

Davidski said...

Yann, as per the above list, what would you consider the best SNPs for predicting fair hair in humans, based on the latest literature?

Yann Klimentidis said...

Davide, I don't really know... other than MC1R for red hair. There may be something out in the literature on the genetics of hair color, I'm just not familiar with it...

Locations of visitors to this page