This is always an interesting yearly paper to look at. It is a review of studies that have found associations between genetic variants and phenotypes such as endurance, muscle strength, training response, hemodynamic traits, insulin and glucose metabolism, fat distribution, blood lipid, exercise intolerance, Vo2max, and more ...
The Human Gene Map for Performance and Health-Related Fitness Phenotypes: The 2005 Update
TUOMO RANKINEN, MOLLY BRAY, JAMES HAGBERG, LOUIS PÉRUSSE, STEPHEN ROTH, BERND WOLFARTH, CLAUDE BOUCHARD
Medicine and Science in Sports & Exercise Volume 38, Number 11 (November 2006)
Abstract: The current review presents the 2005 update of the human gene map for physical performance and health-related fitness phenotypes. It is based on peer-reviewed papers published by the end of 2005. The genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise, or for training-induced changes are positioned on the genetic map of all autosomes and the X chromosome. Negative studies are reviewed, but a gene or locus must be supported by at least one positive study before being inserted on the map. By the end of 2000, in the early version of the gene map, 29 loci were depicted. In contrast, the 2005 human gene map for physical performance and health-related phenotypes includes 165 autosomal gene entries and QTL, plus five others on the X chromosome. Moreover, there are 17 mitochondrial genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes. Thus, the map is growing in complexity. Unfortunately, progress is slow in the field of genetics of fitness and performance, primarily because the number of laboratories and scientists focused on the role of genes and sequence variations in exercise-related traits continues to be quite limited.