I'm not sure where I'm going with this one, but I was just thinking about the climatic conditions during the time humans went into Eurasia and the Americas...it must have been cold.. (much?) colder than it is now. The last ice age seemed to have lasted from about 125,000 years ago to about 20,000 years ago (when it was coldest). Since then, it seems to have warmed up very quickly. This is interesting to think about in terms of recent selection, population differences, strength of selection for skin color etc... Has this selection been relaxed in the last 20,000 years due to the rewarming?
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