Friday, January 02, 2009

Genetic information doesn't add much for predicting diabetes

Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.
van Hoek M, Dehghan A, Witteman JC, van Duijn CM, Uitterlinden AG, Oostra BA, Hofman A, Sijbrands EJ, Janssens AC.
Diabetes. 2008 Nov;57(11):3122-8.
OBJECTIVE: Prediction of type 2 diabetes based on genetic testing might improve identification of high-risk subjects. Genome-wide association (GWA) studies identified multiple new genetic variants that associate with type 2 diabetes. The predictive value of genetic testing for prediction of type 2 diabetes in the general population is unclear. RESEARCH DESIGN AND METHODS: We investigated 18 polymorphisms from recent GWA studies on type 2 diabetes in the Rotterdam Study, a prospective, population-based study among homogeneous Caucasian individuals of 55 years and older (genotyped subjects, n = 6,544; prevalent cases, n = 686; incident cases during follow-up, n = 601; mean follow-up 10.6 years). The predictive value of these polymorphisms was examined alone and in addition to clinical characteristics using logistic and Cox regression analyses. The discriminative accuracy of the prediction models was assessed by the area under the receiver operating characteristic curves (AUCs). RESULTS: Of the 18 polymorphisms, the ADAMTS9, CDKAL1, CDKN2A/B-rs1412829, FTO, IGF2BP2, JAZF1, SLC30A8, TCF7L2, and WFS1 variants were associated with type 2 diabetes risk in our population. The AUC was 0.60 (95% CI 0.57-0.63) for prediction based on the genetic polymorphisms; 0.66 (0.63-0.68) for age, sex, and BMI; and 0.68 (0.66-0.71) for the genetic polymorphisms and clinical characteristics combined. CONCLUSIONS: We showed that 9 of 18 well-established genetic risk variants were associated with type 2 diabetes in a population-based study. Combining genetic variants has low predictive value for future type 2 diabetes at a population-based level. The genetic polymorphisms only marginally improved the prediction of type 2 diabetes beyond clinical characteristics.

1 comment:

Sharon said...


7.9% of the United States population is suffering from a form of Diabetes. That is over 23 million people! Now, more than ever, it is important for organizations such as yourself. We here, at (a site dedicated towards disease and their treatments), believe in the work you do and would like to coincide for the fight against diabetes. If you could, please list us as a resource or host our social book mark button, it would be much appreciated. Separately, we can make advancements, but together we can find a cure.
If you need more information please email me back with the subject line as your URL.

Thank You,
Sharon Vegoe

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